| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 258, Issue 5 1515-H1523, Copyright © 1990 by American Physiological Society
ARTICLES |
J. C. Falcone and H. G. Bohlen
Department of Physiology and Biophysics, Indiana University Medical School, Indianapolis 46223.
Communication from venules to arterioles through the release of endothelial-derived relaxing factor (EDRF) was evaluated. To demonstrate that the rat intestinal and the spinotrapezius muscle arterioles can respond to EDRF, the vessels were dilated by iontophoretically applied acetylcholine (ACh), and this dilation was greatly attenuated by the inhibitors of EDRF actions, methylene blue (100 microM) and dithiothreitol (50 microM). The EDRF inhibitors did not suppress arteriolar dilation to typically applied adenosine (10(-4) M), an endothelium-independent dilator. Although ACh release onto the venular wall had minimal effects on the diameter of the venule, the paired arteriole would dilate 20-30% in the intestine and 50-60% in the spinotrapezius muscle. After EDRF inhibition, venular ACh exposure did not cause arteriolar dilation. ACh diffusion from venules to arterioles was not the cause of arteriolar dilation, because release of ACh into the tissue at the same distance as from the arteriole to the venular ACh release site caused minimal arteriolar dilation. Neither blockade of neural reflexes with tetrodotoxin (3 X 10(-6) M) nor suppression of prostaglandin formation with indomethacin (10(-5) M) prevented the arteriolar dilation during release of ACh onto the venular wall. The overall study indicated that communication from venules to arterioles through the release of EDRF from the venule did occur and caused substantial arteriolar vasodilation. Therefore circumstances within and around venules may influence regulation of nearby arterioles through an EDRF-mediated mechanism.
This article has been cited by other articles:
|
|
 |
|
  S. Coon, G. Shao, S. Wisel, R. Vulaupalli, and U. Sundaram Mechanism of regulation of rabbit intestinal villus cell brush border membrane Na/H exchange by nitric oxide Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G475 - G481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-h. Kim and N. R. Harris Leukocyte adherence inhibits adenosine-dependent venular control of arteriolar diameter and nitric oxide Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H724 - H731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Coon and U. Sundaram Unique regulation of anion/HCO3- exchangers by constitutive nitric oxide in rabbit small intestine Am J Physiol Gastrointest Liver Physiol, December 1, 2003; 285(6): G1084 - G1090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Gill, S. Saksena, I. A. Syed, S. Tyagi, W. A. Alrefai, J. Malakooti, K. Ramaswamy, and P. K. Dudeja Regulation of NHE3 by nitric oxide in Caco-2 cells Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G747 - G756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Hester and L. W. Hammer Venular-arteriolar communication in the regulation of blood flow Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1280 - R1285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-E. Chen, K. Liu, W.-N. Qi, E. Joneschild, X. Tan, A. V. Seaber, J. S. Stamler, and J. R. Urbaniak Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression J Appl Physiol, February 1, 2002; 92(2): 559 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lenda and M. A. Boegehold Effect of a high-salt diet on oxidant enzyme activity in skeletal muscle microcirculation Am J Physiol Heart Circ Physiol, February 1, 2002; 282(2): H395 - H402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Sauls and M. A. Boegehold Adenosine linking reduced O2 to arteriolar NO release in intestine is not formed from extracellular ATP Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1193 - H1200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. W. Hammer, A. L. Ligon, and R. L. Hester ATP-mediated release of arachidonic acid metabolites from venular endothelium causes arteriolar dilation Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2616 - H2622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Bohlen and G. P. Nase Arteriolar nitric oxide concentration is decreased during hyperglycemia-induced {beta}II PKC activation Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H621 - H627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. W. Hammer, A. L. Ligon, and R. L. Hester Differential Inhibition of Functional Dilation of Small Arterioles by Indomethacin and Glibenclamide Hypertension, February 1, 2001; 37(2): 599 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Harris Reperfusion-induced changes in capillary perfusion and filtration: effects of hypercholesterolemia Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H669 - H675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Harris, G. A. M. First, and R. D. Specian Influence of arteriovenular pairing on PAF-induced capillary filtration Am J Physiol Heart Circ Physiol, January 1, 1999; 276(1): H107 - H114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Koller, G. Dornyei, and G. Kaley Flow-induced responses in skeletal muscle venules: modulation by nitric oxide and prostaglandins Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H831 - H836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Bohlen Mechanism of increased vessel wall nitric oxide concentrations during intestinal absorption Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H542 - H550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Vaughn, L. Kuo, and J. C. Liao Effective diffusion distance of nitric oxide in the microcirculation Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1705 - H1714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Jasperse and M. H. Laughlin Flow-induced dilation of rat soleus feed arteries Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2423 - H2427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Groebe Precapillary Servo Control of Blood Pressure and Postcapillary Adjustment of Flow to Tissue Metabolic Status: A New Paradigm for Local Perfusion Regulation Circulation, October 15, 1996; 94(8): 1876 - 1885. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
