| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 257, Issue 6 2059-H2069, Copyright © 1989 by American Physiological Society
ARTICLES |
J. N. Benoit, D. C. Zawieja, A. H. Goodman and H. J. Granger
Microcirculation Research Institute, College of Medicine, Texas A & M University, College Station 77843.
The contractile properties of the mesenteric collecting lymphatics of the rat were analyzed under control conditions and during periods of enhanced lymph formation using in vivo microscopic techniques. Pressure and diameter were simultaneously monitored in microscopic collecting lymphatics, and lymphatic pump function was analyzed in accordance with basic principles of cardiac mechanics. The lymphatic contractile cycle was divided into two phases of systole and four phases of diastole. Under control conditions, lymphatics contracted with a frequency of 6.4 +/- 0.61 beats/min and ejected approximately 67% of their end-diastolic volume. Ten minutes after the rate of lymph formation was elevated by plasma dilution, end-diastolic diameter, contraction frequency, ejection fraction, and stroke volume increased. Pressure in the lymphatic network became less pulsatile in high lymph flow states. Contractility, an index of inotropic changes in lymphatic pump, was unaltered when lymph flow was increased by plasma dilution. Furthermore, the maximal shortening velocity of lymphatic smooth muscle did not change during periods of enhanced lymph flow. Thus it appears that passive increases in the rate of lymph formation exert few, if any, inotropic effects on the lymphatic pump. The augmented stroke volume and contraction frequency appear to result mainly from intrinsic stretch-dependent mechanisms set in motion by elevated preload. These data represent the first comprehensive characterization of both the flow-generating and muscle characteristics of intact collecting lymphatics and provide a basis for future studies on the physiological regulation of lymphatic contraction.
This article has been cited by other articles:
|
|
 |
|
  M. J. Davis, M. M. Lane, A. M. Davis, D. Durtschi, D. C. Zawieja, M. Muthuchamy, and A. A. Gashev Modulation of lymphatic muscle contractility by the neuropeptide substance P Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H587 - H597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Macdonald, K. P. Arkill, G. R. Tabor, N. G. McHale, and C. P. Winlove Modeling flow in collecting lymphatic vessels: one-dimensional flow through a series of contractile elements Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H305 - H313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Dougherty, M. J. Davis, D. C. Zawieja, and M. Muthuchamy Calcium sensitivity and cooperativity of permeabilized rat mesenteric lymphatics Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1524 - R1532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Quick, A. M. Venugopal, R. M. Dongaonkar, G. A. Laine, and R. H. Stewart First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2144 - H2149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Venugopal, R. H. Stewart, G. A. Laine, R. M. Dongaonkar, and C. M. Quick Lymphangion coordination minimally affects mean flow in lymphatic vessels Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1183 - H1189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Meisner, R. H. Stewart, G. A. Laine, and C. M. Quick Lymphatic vessels transition to state of summation above a critical contraction frequency Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R200 - R208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Breslin, N. Gaudreault, K. D. Watson, R. Reynoso, S. Y. Yuan, and M. H. Wu Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H709 - H718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Quick, A. M. Venugopal, A. A. Gashev, D. C. Zawieja, and R. H. Stewart Intrinsic pump-conduit behavior of lymphangions Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1510 - R1518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-z. Zhang, A. A. Gashev, D. C. Zawieja, and M. J. Davis Length-tension relationships of small arteries, veins, and lymphatics from the rat mesenteric microcirculation Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1943 - H1952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. F. Wu, C. J. Carati, W. K. MacNaughton, and P.-Y. von der Weid Contractile activity of lymphatic vessels is altered in the TNBS model of guinea pig ileitis Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G566 - G574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Grimaldi, A. Moriondo, L. Sciacca, M. L. Guidali, G. Tettamanti, and D. Negrini Functional arrangement of rat diaphragmatic initial lymphatic network Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H876 - H885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Gashev, M. D. Delp, and D. C. Zawieja Inhibition of active lymph pump by simulated microgravity in rats Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2295 - H2308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kousai, R. Mizuno, F. Ikomi, and T. Ohhashi ATP inhibits pump activity of lymph vessels via adenosine A1 receptor-mediated involvement of NO- and ATP-sensitive K+ channels Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2585 - H2597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Payne, H.-Y. Zhang, Y. Shirasawa, Y. Koga, M. Ikebe, J. N. Benoit, and S. A. Fisher Dynamic changes in expression of myosin phosphatase in a model of portal hypertension Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1801 - H1810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shirasawa and J. N. Benoit Stretch-induced calcium sensitization of rat lymphatic smooth muscle Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2573 - H2577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hosaka, R. Mizuno, and T. Ohhashi Rho-Rho kinase pathway is involved in the regulation of myogenic tone and pump activity in isolated lymph vessels Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2015 - H2025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shirasawa, F. Ikomi, and T. Ohhashi Physiological roles of endogenous nitric oxide in lymphatic pump activity of rat mesentery in vivo Am J Physiol Gastrointest Liver Physiol, April 1, 2000; 278(4): G551 - G556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Koller, R. Mizuno, and G. Kaley Flow reduces the amplitude and increases the frequency of lymphatic vasomotion: role of endothelial prostanoids Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1999; 277(6): R1683 - R1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Silver, B. Li, J. Szalai, and M. Johnston Relationship between intracranial pressure and cervical lymphatic pressure and flow rates in sheep Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1999; 277(6): R1712 - R1717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mizuno, N. Ono, and T. Ohhashi Involvement of ATP-sensitive K+ channels in spontaneous activity of isolated lymph microvessels in rats Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1453 - H1456. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
