| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 257, Issue 5 1334-H1339, Copyright © 1989 by American Physiological Society
ARTICLES |
M. B. Grisham, L. A. Hernandez and D. N. Granger
Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130.
Ischemia and reperfusion (I/R) of the small intestine initiates a series of events that result in neutrophil-mediated microvascular injury. Recent reports suggest that adenosine possesses anti-inflammatory properties by virtue of its ability to inhibit neutrophil (PMN) superoxide (O2-.) and hydrogen peroxide (H2O2) production and to interfere with PMN adherence to cultured endothelium. In an attempt to further characterize the anti-inflammatory properties of adenosine in vivo we assessed the influence of exogenous adenosine on 1) I/R-induced PMN-mediated microvascular injury in the feline small intestine, 2) feline PMN superoxide production, and 3) I/R-induced PMN adherence to feline mesenteric venular endothelium. We found that intra-arterial administration of adenosine (2 microM) significantly attenuated the I/R-induced increases in intestinal capillary permeability. This protective effect of adenosine could not be explained entirely on its ability to inhibit PMN O2-. (or H2O2) production, since adenosine was effective in inhibiting feline PMN O2-. production by only 20%. Using intravital microscopic techniques in cat mesentery, we found that adenosine did not alter the responses of venular blood flow, shear rate, leukocyte rolling velocity, and leukocyte adherence to I/R when compared with control animals. However, the number of extravasated leukocytes during the ischemic period was significantly reduced by adenosine. Adenosine reduced the number of adherent leukocytes by 25% at 10 and 60 min of reperfusion while leukocyte extravasation was reduced by 65-70% during the same period. Our data indicate that the adenosine-induced suppression of leukocyte extravasation cannot be explained solely by an attenuation in leukocyte adherence to venular endothelium.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  C. S. Bonder, D. Knight, D. Hernandez-Saavedra, J. M. McCord, and P. Kubes Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion Am J Physiol Gastrointest Liver Physiol, September 1, 2004; 287(3): G676 - G684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sola, J. Panes, C. Xaus, and G. Hotter Fructose-1,6-biphosphate and nucleoside pool modifications prevent neutrophil accumulation in the reperfused intestine J. Leukoc. Biol., January 1, 2003; 73(1): 74 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Smolenski, O. Raisky, E. M. Slominska, H. Abunasra, K. K. Kalsi, J. Jayakumar, K. Suzuki, and M. H. Yacoub Protection From Reperfusion Injury After Cardiac Transplantation by Inhibition of Adenosine Metabolism and Nucleotide Precursor Supply Circulation, September 18, 2001; 104(90001): I-246 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nonaka, J. Kiryu, A. Tsujikawa, K. Yamashiro, K. Nishijima, K. Miyamoto, H. Nishiwaki, Y. Honda, and Y. Ogura Inhibitory Effect of Ischemic Preconditioning on Leukocyte Participation in Retinal Ischemia-Reperfusion Injury Invest. Ophthalmol. Vis. Sci., September 1, 2001; 42(10): 2380 - 2385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Boyle, E. A. Kowaluk, M. F. Jarvis, C.-H. Lee, S. S. Bhagwat, M. Williams, and G. S. Firestein Anti-Inflammatory Effects of ABT-702, a Novel Non-Nucleoside Adenosine Kinase Inhibitor, in Rat Adjuvant Arthritis J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 495 - 500. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. R. Lee, J. J. Han, and J. W. Seo Correlation between ICAM-1 and functional recovery of piglet myocardium with leukocyte-depleted reperfusion Ann. Thorac. Surg., November 1, 2000; 70(5): 1531 - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. FLAMAND, S. BOUDREAULT, S. PICARD, M. AUSTIN, M. E. SURETTE, H. PLANTE, E. KRUMP, M.-J. VALLEE, C. GILBERT, P. NACCACHE, et al. Adenosine, a Potent Natural Suppressor of Arachidonic Acid Release and Leukotriene Biosynthesis in Human Neutrophils Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): S88 - 94. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kubes, D. Payne, and L. Ostrovsky Preconditioning and adenosine in I/R-induced leukocyte-endothelial cell interactions Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1230 - H1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bauer, M. G. Bouma, I. Herrmann, F. A. J. M. Van Den Wildenberg, G. S. Firestein, I. Marzi, and W. A. Buurman Adenosine kinase inhibitor GP515 attenuates hepatic leukocyte adhesion after hemorrhagic hypotension Am J Physiol Gastrointest Liver Physiol, December 1, 1997; 273(6): G1297 - G1303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ostrovsky, R. C. Woodman, D. Payne, D. Teoh, and P. Kubes Antithrombin III Prevents and Rapidly Reverses Leukocyte Recruitment in Ischemia/Reperfusion Circulation, October 7, 1997; 96(7): 2302 - 2310. [Abstract] [Full Text]
|
|
|
|
|
|
J. Panes, I. Kurose, M. D. Rodriguez-Vaca, D. C. Anderson, M. Miyasaka, P. Tso, and D. N. Granger Diabetes Exacerbates Inflammatory Responses to Ischemia-Reperfusion Circulation, January 1, 1996; 93(1): 161 - 167. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Galinanes, X. Zhai, D. Bullough, K. M. Mullane, and D. J. Hearse Protection against injury during ischemia and reperfusion by acadesine derivatives GP-1-468 and GP-1-668Studies in the transplanted rat heart J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 752 - 761. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
