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Am J Physiol Heart Circ Physiol 257: H1235-H1239, 1989;
0363-6135/89 $5.00
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AJP - Heart and Circulatory Physiology, Vol 257, Issue 4 1235-H1239, Copyright © 1989 by American Physiological Society

ARTICLES

Similar responsiveness of smooth muscle of the canine basilar artery to EDRF and nitric oxide

Z. S. Katusic, J. J. Marshall, H. A. Kontos and P. M. Vanhoutte
Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905.

Experiments were designed to compare the reactivity of canine basilar arteries to endothelium-derived relaxing factor (EDRF) and nitric oxide. Preparations with endothelium activated by bradykinin were used to study relaxations induced with EDRF, whereas the inhibitory effect of nitric oxide was studied in preparations without endothelium. All experiments were performed in the presence of indomethacin. EDRF- and nitric oxide-induced relaxations were significantly augmented in the presence of superoxide dismutase plus catalase but were reduced in the presence of methylene blue, LY 83583, and hemoglobin. M & B 22984 did not affect relaxations to either EDRF or nitric oxide. These results indicate that in the canine basilar artery EDRF is not an oxygen-derived free radical. The similar responsiveness of the basilar artery to EDRF and nitric oxide is consistent with the proposal that in the canine basilar artery nitric oxide is the factor.


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