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Am J Physiol Heart Circ Physiol 257: H635-H642, 1989;
0363-6135/89 $5.00
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AJP - Heart and Circulatory Physiology, Vol 257, Issue 2 635-H642, Copyright © 1989 by American Physiological Society

ARTICLES

Sequential topographical portrayal of myocardial blood flow

J. F. Richeson, R. C. Waag, D. Zwierzynski and E. A. Schenk
Department of Pathology, University of Rochester School of Medicine and Dentistry, New York 14642.

Methods to portray myocardial blood flow in a two-dimensional continuum are advantageous in that they allow blood flow history to be overlaid on histological or histochemical descriptions of the consequences of ischemia. We describe here autoradiographic methods that allow such portrayals at three separate times during the evolution of ischemic injury. A computer-based image-analysis system was used to derive such flow maps by taking advantage of the physical characteristics of radioactive isotopes.




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