AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 257: H597-H602, 1989;
0363-6135/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scott, D. P.
Right arrow Articles by Coburn, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scott, D. P.
Right arrow Articles by Coburn, R. F.

AJP - Heart and Circulatory Physiology, Vol 257, Issue 2 597-H602, Copyright © 1989 by American Physiological Society

ARTICLES

Phosphocreatine and oxidative metabolism-contraction coupling in rabbit aorta

D. P. Scott and R. F. Coburn
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104.

Oxidative metabolism-contraction coupling was studied in single rabbit aortic rings by measuring changes in phosphocreatine (PCr) and ATP content, the ratio of PCr to free creatine (Cr), and changes in muscle force under conditions in which cellular energy production was inhibited. We compared rings with markedly different total PCr content by using rings loaded with creatine, control (unloaded) rings, and rings exposed for 30 min to zero-glucose solution. Creatine loading resulted in increases in PCr content to 300% of control. Maintained muscle force generated by 30 microM norepinephrine was decreased by hypoxia, 0.05 and 0.1 mM cyanide, removal of glucose from the bathing media, or glucose removal plus hypoxia. There was no difference between creatine-loaded and unloaded rings in the mechanical effects of these perturbations. Changes in muscle force induced by inhibition of energy production using the various perturbations correlated with changes in PCr/Cr. Data are consistent with oxidative metabolism-contraction coupling being regulated by energy delivery to a reaction or reactions controlling muscle force. Metabolism-contraction coupling is not controlled by total energy stores or by PCr or Cr concentration.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. M. Leach, D. W. Sheehan, V. P. Chacko, and J. T. Sylvester
Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries
Am J Physiol Lung Cell Mol Physiol, February 1, 2000; 278(2): L294 - L304.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. M. Leach, D. W. Sheehan, V. P. Chacko, and J. T. Sylvester
Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles
Am J Physiol Lung Cell Mol Physiol, December 1, 1998; 275(6): L1051 - L1060.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online