| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 256, Issue 3 621-H625, Copyright © 1989 by American Physiological Society
ARTICLES |
W. G. Mayhan
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, 52242.
The goal of this study was to determine whether responses of cerebral arterioles to vasoactive substances released by platelets are altered during diabetes mellitus. To induce diabetes, rats were injected with streptozotocin (50-60 mg/kg ip). Rats were characterized as diabetic by a blood glucose of greater than 300 mg/dl. Diameter of pial arterioles was measured during superfusion with ADP, serotonin, and the thromboxane analogue (U-46619), with the use of intravital microscopy in control (non-diabetic) and diabetic rats. ADP (10(-5)M) increased pial arteriolar diameter by 13 +/- 1% (mean +/- SE) in control rats and did not change diameter of arterioles in diabetic rats (1 +/- 1%). Serotonin (10(-5)M) increased diameter of cerebral arterioles by 9 +/- 1% in control rats and constricted arterioles by 5 +/- 2% in diabetic rats. Nitroglycerin produced similar dilatation of cerebral arterioles in control and diabetic rats, suggesting that impaired dilatation of cerebral arterioles in diabetic rats was not related to nonspecific impairment of vasodilatation. The thromboxane analogue U-46619 produced similar constriction of cerebral arterioles in control and diabetic rats. Thus endothelium-dependent dilatation of cerebral arterioles in response to ADP and serotonin is profoundly impaired in diabetic rats.
This article has been cited by other articles:
|
|
 |
|
  A. K. Harris, M. M. Elgebaly, W. Li, K. Sachidanandam, and A. Ergul Effect of chronic endothelin receptor antagonism on cerebrovascular function in type 2 diabetes Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1213 - R1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Xiang, J. S. Naik, S. R. Abram, and R. L. Hester Chronic hyperglycemia impairs functional vasodilation via increasing thromboxane-receptor-mediated vasoconstriction Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H231 - H236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lavi, D. Gaitini, V. Milloul, and G. Jacob Impaired cerebral CO2 vasoreactivity: association with endothelial dysfunction Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1856 - H1861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Phillips, F. A. Sylvester, and J. C. Frisbee Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R522 - R530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Mayhan, H. Sun, J. F. Mayhan, and K. P. Patel Influence of exercise on dilatation of the basilar artery during diabetes mellitus J Appl Physiol, May 1, 2004; 96(5): 1730 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Kennedy and D. W. Zochodne Influence of Experimental Diabetes on the Microcirculation of Injured Peripheral Nerve: Functional and Morphological Aspects Diabetes, July 1, 2002; 51(7): 2233 - 2240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nitenberg, S. Ledoux, P. Valensi, R. Sachs, J.-R. Attali, and I. Antony Impairment of Coronary Microvascular Dilation in Response to Cold Pressor-Induced Sympathetic Stimulation in Type 2 Diabetic Patients With Abnormal Stress Thallium Imaging Diabetes, May 1, 2001; 50(5): 1180 - 1185. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Kimura, M. Oike, T. Koyama, and Y. Ito Impairment of endothelial nitric oxide production by acute glucose overload Am J Physiol Endocrinol Metab, January 1, 2001; 280(1): E171 - E178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. H. Thourani, W. S. Weintraub, B. Stein, S. S.P. Gebhart, J. M. Craver, E. L. Jones, and R. A. Guyton Influence of diabetes mellitus on early and late outcome after coronary artery bypass grafting Ann. Thorac. Surg., April 1, 1999; 67(4): 1045 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Mayhan and K. P. Patel Treatment with dimethylthiourea prevents impaired dilatation of the basilar artery during diabetes mellitus Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H1895 - H1901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Williams, A. B. Goldfine, F. K. Timimi, H. H. Ting, M.-A. Roddy, D. C. Simonson, and M. A. Creager Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo Circulation, May 5, 1998; 97(17): 1695 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kimura, M. Oike, and Y. Ito Acute Glucose Overload Abolishes Ca2+ Oscillation in Cultured Endothelial Cells From Bovine Aorta : A Possible Role of Superoxide Anion Circ. Res., April 6, 1998; 82(6): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nitenberg, F. Paycha, S. Ledoux, R. Sachs, J.-R. Attali, and P. Valensi Coronary Artery Responses to Physiological Stimuli Are Improved by Deferoxamine but not by L-Arginine in Non–Insulin-Dependent Diabetic Patients With Angiographically Normal Coronary Arteries and No Other Risk Factors Circulation, March 3, 1998; 97(8): 736 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. FARACI and D. D. HEISTAD Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels Physiol Rev, January 1, 1998; 78(1): 53 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Zimmermann, H. J. Knot, A. S. Stevenson, and M. T. Nelson Increased Myogenic Tone and Diminished Responsiveness to ATP-Sensitive K+ Channel Openers in Cerebral Arteries From Diabetic Rats Circ. Res., December 19, 1997; 81(6): 996 - 1004. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. M. Pieper and L. A. Dondlinger Plasma and Vascular Tissue Arginine Are Decreased in Diabetes: Acute Arginine Supplementation Restores Endothelium-Dependent Relaxation by Augmenting cGMP Production J. Pharmacol. Exp. Ther., November 1, 1997; 283(2): 684 - 691. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J. Cipolla, J. M. Porter, G. Osol, and W. G. Mayhan High Glucose Concentrations Dilate Cerebral Arteries and Diminish Myogenic Tone Through an Endothelial Mechanism Stroke, February 1, 1997; 28(2): 405 - 411. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Lambert, M. Aarsen, A. J.M. Donker, and C. D.A. Stehouwer Endothelium-Dependent and -Independent Vasodilation of Large Arteries in Normoalbuminuric Insulin-Dependent Diabetes Mellitus Arterioscler. Thromb. Vasc. Biol., May 1, 1996; 16(5): 705 - 711. [Abstract] [Full Text]
|
|
|
|
|
|
W. G. Mayhan and S. P. Didion Acute Effects of Ethanol on Responses of Cerebral Arterioles Stroke, November 1, 1995; 26(11): 2097 - 2102. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kitazono, F. M. Faraci, H. Taguchi, and D. D. Heistad Role of Potassium Channels in Cerebral Blood Vessels Stroke, September 1, 1995; 26(9): 1713 - 1723. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
