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Am J Physiol Heart Circ Physiol 256: H589-H593, 1989;
0363-6135/89 $5.00
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AJP - Heart and Circulatory Physiology, Vol 256, Issue 2 589-H593, Copyright © 1989 by American Physiological Society

ARTICLES

Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

T. H. Liu, J. S. Beckman, B. A. Freeman, E. L. Hogan and C. Y. Hsu
Department of Neurology, Medical University of South Carolina, Charleston 29425-2232.

Superoxide dismutase and catalase enzymatically scavenge superoxide and hydrogen peroxide, respectively. Conjugation of polyethylene glycol to superoxide dismutase (PEG-SOD) or catalase (PEG-CAT) prolongs the circulatory half-life of the native enzymes and enhances their intracellular access. We studied the protective effect of these free radical scavengers on ischemic brain injury using a rat model of focal cerebral ischemia, which is suitable for therapeutic trials. Intravenous administration of PEG-SOD (10,000 U/kg) and PEG-CAT (10,000 U/kg) before ischemia reduced the infarct volume (treatment, 139 +/- 9 mm3, means +/- SE, N = 38; placebo, 182 +/- 8 mm3, n = 37, P less than 0.002). This finding supports the concept that superoxide and hydrogen peroxide contribute to brain injury following focal cerebral ischemia.


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