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Am J Physiol Heart Circ Physiol 253: H709-H711, 1987;
0363-6135/87 $5.00
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AJP - Heart and Circulatory Physiology, Vol 253, Issue 3 709-H711, Copyright © 1987 by American Physiological Society

ARTICLES

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

L. J. Eddy, J. R. Stewart, H. P. Jones, T. D. Engerson, J. M. McCord and J. M. Downey

Samples from four human hearts were analyzed for both their xanthine dehydrogenase and xanthine oxidase content. We used the conventional spectrophotometric assay and a more sensitive fluorometric assay to determine the content of enzyme in these samples. In no case could any activity be detected. We conclude that human hearts must contain less than 2.0 nU/g of activity. This makes it unlikely that xanthine oxidase is a significant source of O2 free radicals in the ischemic human heart or that xanthine oxidase inhibitors will be of therapeutic value in that setting.


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