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Am J Physiol Heart Circ Physiol 252: H771-H776, 1987;
0363-6135/87 $5.00
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AJP - Heart and Circulatory Physiology, Vol 252, Issue 4 771-H776, Copyright © 1987 by American Physiological Society

ARTICLES

Developmental changes in the response of cardiac Purkinje fibers to SC-72-14

Y. Morikawa, M. R. Rosen, H. Meiri and R. B. Robinson

We used standard microelectrode techniques to study the effects of SC-72-14, a monoclonal antibody to eel electroplax, and tetrodotoxin (TTX) on the electrophysiological properties of neonatal and adult canine Purkinje fibers. SC-72-14, 7 ng/ml, depressed maximum upstroke potential (Vmax) and membrane responsiveness of adult but not neonatal fibers. In contrast, we previously had shown TTX to have a greater effect on neonatal than adult fibers (29). Even in the presence of SC-72-14, TTX continued to have a greater effect on the neonatal fibers. The effects of TTX and SC-72-14 were cumulative over the concentration range studied, and our results are consistent with their acting at different sites.




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