AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 252: H142-H148, 1987;
0363-6135/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Escande, D.
Right arrow Articles by Coraboeuf, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Escande, D.
Right arrow Articles by Coraboeuf, E.

AJP - Heart and Circulatory Physiology, Vol 252, Issue 1 142-H148, Copyright © 1987 by American Physiological Society

ARTICLES

Two types of transient outward currents in adult human atrial cells

D. Escande, A. Coulombe, J. F. Faivre, E. Deroubaix and E. Coraboeuf

It has been suggested in a previous article [Escande et al., Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H843-H850, 1985] that transient outward currents may participate in the initial repolarization of human atrial fibers. The present study substantiates the existence of such currents in human myocardium. Membrane currents were recorded in enzymatically dissociated cells using the whole cell patch-clamp technique. Two kinds of transient outward currents were observed: 1) a long-lasting outward current, (ilo), which was suppressed by 4-aminopyridine. The time to peak of ilo was 18.0 +/- 0.7 ms, and its inactivation time constant was 35.7 +/- 2.1 ms at room temperature (test pulses, +20 mV; holding potential, -40 mV); 2) a brief outward current (ibo), which persisted with 3 mM 4-aminopyridine and exhibited a shorter time to peak (5.5 +/- 0.2 ms) and a faster decay (time constant, 9.1 +/- 1.8 ms). ilo was inhibited by Ba but was insensitive to the calcium blocker Co. Co blocked both the slow inward current (isi) and ibo. It is concluded that two different transient outward currents control the repolarization in human atrial cells.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Guo, L. Young, C. Patel, Z. Jiao, Y. Wu, T. Liu, P. R. Kowey, and G.-X. Yan
Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit
Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H97 - H104.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
H. E. D. J. ter Keurs and P. A. Boyden
Calcium and Arrhythmogenesis
Physiol Rev, April 1, 2007; 87(2): 457 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Zhang, J. Xiao, H. Wang, X. Luo, J. Wang, L. R. Villeneuve, H. Zhang, Y. Bai, B. Yang, and Z. Wang
Restoring depressed HERG K+ channel function as a mechanism for insulin treatment of abnormal QT prolongation and associated arrhythmias in diabetic rabbits
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1446 - H1455.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Zicha, I. Moss, B. Allen, A. Varro, J. Papp, R. Dumaine, C. Antzelevich, and S. Nattel
Molecular basis of species-specific expression of repolarizing K+ currents in the heart
Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1641 - H1649.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Czarnecki, L. Dufy-Barbe, S. Huet, M.-F. Odessa, and L. Bresson-Bepoldin
Potassium channel expression level is dependent on the proliferation state in the GH3 pituitary cell line
Am J Physiol Cell Physiol, April 1, 2003; 284(4): C1054 - C1064.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Xu, P. H. Dong, Z. Zhang, G. U. Ahmmed, and N. Chiamvimonvat
Presence of a calcium-activated chloride current in mouse ventricular myocytes
Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H302 - H314.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. Godreau, R. Vranckx, and S. N. Hatem
Mechanisms of Action of Antiarrhythmic Agent Bertosamil on hKv1.5 Channels and Outward Potassium Current in Human Atrial Myocytes
J. Pharmacol. Exp. Ther., February 1, 2002; 300(2): 612 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Czarnecki, S. Vaur, L. Dufy-Barbe, B. Dufy, and L. Bresson-Bepoldin
Cell cycle-related changes in transient K+ current density in the GH3 pituitary cell line
Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1819 - C1828.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y.-G. Wang, M. B. Wagner, R. Kumar, W. N. Goolsby, and R. W. Joyner
Fast pacing facilitates discontinuous action potential propagation between rabbit atrial cells
Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2095 - H2103.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
H. S. Cho, J. J. Lee, I. S. Chung, B. S. Shin, J. A. Kim, and K. H. Lee
Insulin Reverses Bupivacaine-Induced Cardiac Depression in Dogs
Anesth. Analg., October 1, 2000; 91(5): 1096 - 1102.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. O. Verkerk, M. W. Veldkamp, L. N. Bouman, and A. C. G. van Ginneken
Calcium-Activated Cl- Current Contributes to Delayed Afterdepolarizations in Single Purkinje and Ventricular Myocytes
Circulation, June 6, 2000; 101(22): 2639 - 2644.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. R. Hume, D. Duan, M. L. Collier, J. Yamazaki, and B. Horowitz
Anion Transport in Heart
Physiol Rev, January 1, 2000; 80(1): 31 - 81.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. T. Hulme and C. H. Orchard
Effect of acidosis on transient outward potassium current in isolated rat ventricular myocytes
Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H50 - H59.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Tessier, P. Karczewski, E.-G. Krause, Y. Pansard, C. Acar, M. Lang-Lazdunski, J.-J. Mercadier, and S. N. Hatem
Regulation of the Transient Outward K+ Current by Ca2+/Calmodulin-Dependent Protein Kinases II in Human Atrial Myocytes
Circ. Res., October 29, 1999; 85(9): 810 - 819.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Z. Wang, J. Feng, H. Shi, A. Pond, J. M. Nerbonne, and S. Nattel
Potential Molecular Basis of Different Physiological Properties of the Transient Outward K+ Current in Rabbit and Human Atrial Myocytes
Circ. Res., March 19, 1999; 84(5): 551 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Zhou, A. Jeron, B. London, X. Han, and G. Koren
Characterization of a Slowly Inactivating Outward Current in Adult Mouse Ventricular Myocytes
Circ. Res., October 19, 1998; 83(8): 806 - 814.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. S. Lee and E. W. Lee
Ionic Mechanism of Ibutilide in Human Atrium: Evidence for a Drug-Induced Na+ Current Through a Nifedipine Inhibited Inward Channel
J. Pharmacol. Exp. Ther., July 1, 1998; 286(1): 9 - 22.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Courtemanche, R. J. Ramirez, and S. Nattel
Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model
Am J Physiol Heart Circ Physiol, July 1, 1998; 275(1): H301 - H321.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
R. F. Shaffer, C. M. Baumgarten, and R. J. Damiano Jr.
Prevention of cellular edema directly caused by hypothermic cardioplegia: Studies in isolated human and rabbit atrial myocytes
J. Thorac. Cardiovasc. Surg., May 1, 1998; 115(5): 1189 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. P. Baskin and J. J. Lynch Jr.
Differential Atrial versus Ventricular Activities of Class III Potassium Channel Blockers
J. Pharmacol. Exp. Ther., April 1, 1998; 285(1): 135 - 142.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
A. Nygren, C. Fiset, L. Firek, J. W. Clark, D. S. Lindblad, R. B. Clark, and W. R. Giles
Mathematical Model of an Adult Human Atrial Cell : The Role of K+ Currents in Repolarization
Circ. Res., January 23, 1998; 82(1): 63 - 81.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Bailly, J.-P. Benitah, M. Mouchoniere, G. Vassort, and P. Lorente
Regional Alteration of the Transient Outward Current in Human Left Ventricular Septum During Compensated Hypertrophy
Circulation, August 19, 1997; 96(4): 1266 - 1274.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
D. R. Van Wagoner, A. L. Pond, P. M. McCarthy, J. S. Trimmer, and J. M. Nerbonne
Outward K+ Current Densities and Kv1.5 Expression Are Reduced in Chronic Human Atrial Fibrillation
Circ. Res., June 19, 1997; 80(6): 772 - 781.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. Feng, Z. Wang, G.-R. Li, and S. Nattel
Effects of Class III Antiarrhythmic Drugs on Transient Outward and Ultra-rapid Delayed Rectifier Currents in Human Atrial Myocytes
J. Pharmacol. Exp. Ther., April 1, 1997; 281(1): 384 - 392.
[Abstract] [Full Text]

Home page
 CirculationHome page
A. Goette, C. Honeycutt, and J. J. Langberg
Electrical Remodeling in Atrial Fibrillation: Time Course and Mechanisms
Circulation, December 1, 1996; 94(11): 2968 - 2974.
[Abstract] [Full Text]

Home page
 CirculationHome page
L. Fananapazir, D. Packer, and E. N. Prystowsky
Differential Effects of Changes in Local Myocardial Refractoriness on Atrialand Ventricular Latency
Circulation, September 15, 1996; 94(6): 1364 - 1371.
[Abstract] [Full Text]

Home page
 CirculationHome page
C. Valenzuela, E. Delpon, L. Franqueza, P. Gay, O. Perez, J. Tamargo, and D. J. Snyders
Class III Antiarrhythmic Effects of Zatebradine: Time-, State-, Use-, and Voltage-Dependent Block of hKv1.5 Channels
Circulation, August 1, 1996; 94(3): 562 - 570.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
G.-R. Li, J. Feng, Z. Wang, B. Fermini, and S. Nattel
Adrenergic Modulation of Ultrarapid Delayed Rectifier K+ Current in Human Atrial Myocytes
Circ. Res., May 1, 1996; 78(5): 903 - 915.
[Abstract] [Full Text]

Home page
 CirculationHome page
M. Nabauer, D. J. Beuckelmann, P. Uberfuhr, and G. Steinbeck
Regional Differences in Current Density and Rate-Dependent Properties of the Transient Outward Current in Subepicardial and Subendocardial Myocytes of Human Left Ventricle
Circulation, January 1, 1996; 93(1): 168 - 177.
[Abstract] [Full Text]

Home page
 CirculationHome page
T. Yamashita, T. Nakajima, H. Hazama, E. Hamada, Y. Murakawa, K. Sawada, and M. Omata
Regional Differences in Transient Outward Current Density and Inhomogeneities of Repolarization in Rabbit Right Atrium
Circulation, November 15, 1995; 92(10): 3061 - 3069.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
W. J. Crumb Jr, J. D. Pigott, and C. W. Clarkson
Description of a Nonselective Cation Current in Human Atrium
Circ. Res., November 1, 1995; 77(5): 950 - 956.
[Abstract] [Full Text]

Home page
 CirculationHome page
H. Konarzewska, G. A. Peeters, and M. C. Sanguinetti
Repolarizing K+ Currents in Nonfailing Human Hearts : Similarities Between Right Septal Subendocardial and Left Subepicardial Ventricular Myocytes
Circulation, September 1, 1995; 92(5): 1179 - 1187.
[Abstract] [Full Text]

Home page
 CirculationHome page
C. I. Berul and M. Morad
Regulation of Potassium Channels by Nonsedating Antihistamines
Circulation, April 15, 1995; 91(8): 2220 - 2225.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
B. A. Wible, M. De Biasi, K. Majumder, M. Taglialatela, and A. M. Brown
Cloning and Functional Expression of an Inwardly Rectifying K+ Channel From Human Atrium
Circ. Res., March 1, 1995; 76(3): 343 - 350.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online