AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 252: H118-H124, 1987;
0363-6135/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buckley, N. M.
Right arrow Articles by Frasier, I. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buckley, N. M.
Right arrow Articles by Frasier, I. D.

AJP - Heart and Circulatory Physiology, Vol 252, Issue 1 118-H124, Copyright © 1987 by American Physiological Society

ARTICLES

Autoregulatory escape from vasoconstriction of intestinal circulation in developing swine

N. M. Buckley, M. Jarenwattananon, P. M. Gootman and I. D. Frasier

The capability of the developing intestinal circulation to maintain a vasoconstrictor response during postganglionic adrenergic nerve stimulation or norepinephrine infusion was examined in 34 swine aged 6 h to 2 mo anesthetized with pentobarbital sodium. Aortic and portal venous pressures, electrocardiogram (ECG), and blood flow (F) through the superior mesenteric artery were recorded, and intestinal vascular resistance (MVR) was calculated as mean pressure difference per mean F. Baroreceptor reflex inhibition by bilateral occlusion of the carotid arteries increased MVR, section of the splanchnic nerve and postganglionic fibers decreased MVR, and short-latency F decreases were obtained during mesenteric nerve stimulation (MNS). Latencies for the decreases in F shortened with age and with increasing MNS frequency (5-17 Hz) at any age. Prolonging MNS for 60 s at 10 or 12 Hz led to sustained high MVR in 6-h to 7-day-old animals; however, MVR decreased toward control before the end of the 60-s MNS period in animals 1 to 2 mo old. Intra-arterial infusion of norepinephrine (0.5 microgram X kg-1 X min-1) decreased F and increased MVR in all animals; but by 5 min of infusion, F was returning toward control level in all but the youngest. This demonstration that the least mature intestinal circulation was least capable of autoregulatory escape from vasoconstriction provides further evidence of its functional immaturity.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. M. Reber, B. Y. Su, K. R. Clark, D. L. Pohlman, C. E. Miller, and P. T. Nowicki
Developmental expression of eNOS in postnatal swine mesenteric artery
Am J Physiol Gastrointest Liver Physiol, December 1, 2002; 283(6): G1328 - G1335.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. T. Nowicki
Effects of sustained low-flow perfusion on the response to vasoconstrictor agents in postnatal intestine
Am J Physiol Gastrointest Liver Physiol, June 1, 1999; 276(6): G1408 - G1416.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. T. Nowicki and L. A. Minnich
Effects of systemic hypotension on postnatal intestinal circulation: role of angiotensin
Am J Physiol Gastrointest Liver Physiol, February 1, 1999; 276(2): G341 - G352.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online