AJP - Heart and Circulatory Physiology, Vol 251, Issue 4 742-H747, Copyright © 1986 by American Physiological Society

ARTICLES

Absence of sustained hypertension in sinoaortic-denervated rabbits

M. Saito, N. Terui, Y. Numao and M. Kumada

In 21 conscious unrestrained rabbits, arterial pressure was continuously recorded up to 11 wk by an indwelling catheter placed in the thoracic aorta. The average and standard deviation of the 24-h mean arterial pressure (MAP) were calculated and compared before and after sinoaortic denervation, sham operation, or cervical sympathectomy. At the time of sinoaortic denervation, the cervical sympathetic nerve was always disrupted bilaterally to remove possible arterial barosensory afferents contained in it. Subsequent to sinoaortic denervation performed on 12 rabbits, the average 24-h MAP was initially elevated but invariably returned to the predenervation level in 5-36 days (average 14 days). Meanwhile, the standard deviation remained elevated in all but one animal. In five sham-operated or four cervical-sympathectomized animals, neither the average 24-h MAP nor the standard deviation was significantly altered from that of controls. Our results are consistent with the view that the arterial baroreceptor reflex by itself does not play a critical role in determining the long-term level of arterial pressure.

This article has been cited by other articles:

				T. N. Thrasher Baroreceptors, baroreceptor unloading, and the long-term control of blood pressure Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R819 - R827. [Abstract] [Full Text] [PDF]

				C. J. Barrett and S. C. Malpas Problems, possibilities, and pitfalls in studying the arterial baroreflexes' influence over long-term control of blood pressure Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R837 - R845. [Abstract] [Full Text] [PDF]

				J. W. Osborn, F. Jacob, and P. Guzman A neural set point for the long-term control of arterial pressure: beyond the arterial baroreceptor reflex Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R846 - R855. [Abstract] [Full Text] [PDF]

				T. N. Thrasher Effects of chronic baroreceptor unloading on blood pressure in the dog Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R863 - R871. [Abstract] [Full Text] [PDF]

				J.-K. Kim, J. A. Sala-Mercado, J. Rodriguez, T. J. Scislo, and D. S. O'Leary Arterial baroreflex alters strength and mechanisms of muscle metaboreflex during dynamic exercise Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1374 - H1380. [Abstract] [Full Text] [PDF]

				S. C. Malpas What sets the long-term level of sympathetic nerve activity: is there a role for arterial baroreceptors? Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R1 - R12. [Abstract] [Full Text] [PDF]