AJP - Heart and Circulatory Physiology, Vol 251, Issue 4 689-H692, Copyright © 1986 by American Physiological Society
Zona glomerulosa cell responses to atrial natriuretic factor in genetically hypertensive rats
K. Racz, O. Kuchel, N. T. Buu, J. Gutkowska, W. Debinski, M. Cantin and J. Genest
We examined whether abnormalities in target cell responsiveness to atrial
natriuretic factor (ANF), similar to those previously found in the kidney,
could also be present in the zona glomerulosa cells of spontaneously
hypertensive rats (SHR) and salt-sensitive Dahl rats (S rats). We found an
attenuated aldosterone (Aldo) response to angiotensin II (ANG II) in zona
glomerulosa cell suspensions isolated from hypertensive SHR compared with
those from Wistar-Kyoto (WKY) rats, whereas cells derived from hypertensive
S rats showed a significantly higher Aldo response to the maximum
stimulatory dose of ANG II than those from salt-resistant Dahl rats (R
rats). The maximum observed Aldo responses to ACTH stimulation were not
different in SHR or S rats compared with their respective controls. ANF
exerted a potent inhibitory action on both ANG II- and ACTH-stimulated
secretions of glomerulosa cell suspensions, without any difference in its
potency between hypertensive and control rats. The equipotent inhibitory
action of ANF on the ANG II- and ACTH-stimulated secretion of Aldo in those
cell suspensions suggests that the previously observed alterations in the
target cell responsiveness to ANF do not exist in the adrenal zona
glomerulosa cells of SHR and Dahl S rats.
