Status epilepticus (SE) is a seizure or series of seizures that persist for >30 min, and often results in mortality. Death rarely occurs during or immediately following seizure activity, but usually within 30 days. Although ventricular arrhythmias have been implicated in SE-related mortality, the effects of this prolonged seizure activity on the cardiac function, and susceptibility to arrhythmias have not been directly investigated. We evaluated myocardial damage, alterations in cardiac electrical activity, and susceptibility to experimentally-induced arrhythmias produced by SE in rats. SE resulted in seizure-related increases in blood pressure, heart rate, and dP/dt, as well as modest, diffuse myocyte damage assessed by TUNEL staining. Ten-12 days following seizures, electrocardiographic recordings showed arrhythmogenic alterations in cardiac electrical activity, denoted by prolonged QTc interval, and QT dispersion. Finally, SE increased susceptibility to experimentally-induced (iv aconitine) cardiac arrhythmias. These data suggest that SE produces tachycardic ischemia following activation of the sympathetic nervous system, resulting in cardiac myofilament damage, arrhythmogenic alterations in cardiac electrical activity, and increased susceptibility to ventricular arrhythmias.